Identification of Genetic Mutations of Complement Genes in Renal and Retinal Disease C3 Glomerulopathy, HUS and AMD

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Department of Infection Biology invites talented and highly gifted candidates to apply for a

Doctoral Researcher (Infection Biology)

25/2016

for two years initially.

Successful candidates will investigate the field Complement Genetics in Renal and Retinal Diseases. Main topics of the project are

Identification of Genetic Mutations of Complement Genes in Renal and Retinal Disease C3 Glomerulopathy, HUS and AMD

Next Generation Sequencing for Genetic Diagnostics
Functional characterization of CFHR1, CFHR3 and CFHR5 proteins
For further details please see literature below.

Weitere Informationen

Unternehmen

Leibniz-Gemeinschaft

Abschlussart

Dissertation

Ansprechpartner/in

Please contact Peter Zipfel | +49 3641 532 1300 | peter.zipfel(at)leibniz-hki.de

Branche

Bio- und Gentechnologie

Anforderungen

Master degree in biology, genetics or life sciences
Experience, knowledge and good experimental skills in molecular biology, genetic, biochemistry are an advantage

Zusatzinformationen

Literature:

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF (2016) CFHR5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol, in press

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Büttner M, Goodship T, Hugo C, Skerka C, Zipfel PF (2014) Complement factor H related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124, 145-155

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Córdoba SR, Noris M, Pickering M, Smith R (2015) The role of Complement in C3 Glomerulopathy. Mol Immunol 67(1):21-30

Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740

Leistungen

Finanzielle Unterstützung

› Salary is paid according to German TV-L (salary agreement for public service employees).